I've found hope and inspiration on this site, so I thought I would add my story in case it helps anyone. I have 2 daughters (4 and 6) that I conceived early on in my 30s with no difficulty. After just turning 36, we wanted to complete our family with a third, but nothing happened. After much testing, I was diagnosed with unexplained infertility. The only difference I noticed was that I always got spotting on day 25 or so of my cycle, until full period around day 28. I always knew I was out for the cycle when I got that spotting!! After 5 rounds of clomid and no BFPs later, we thought about calling it quits and counting our blessings, but I could never get past my desire for another child. At the beginning of this year, we made the big decision to go for IVF. We were self-pay so I told myself this was the one and only chance, and that hopefully I could get closure if nothing else! I did gonal-f and ganerelix protocol, and only got 5 eggs, 4 fertilized, and only 2 made it to day 3. We did a day 3 transfer of 2 8-cell embryos, and two weeks later I got the dreaded spotting and just knew it failed. My beta was 10 - it was a chemical pregnancy. 4 months later, I wanted to try again. I felt like a new protocol based on learnings from the first, could make a big difference. So we went into debt to do it again. This time I asked them to check my thyroid again, because I had heard that its really important the TSH is under 2.5. Mine was 2.97, and they decided to treat it with medication. Going forward with the IVF Round 2, I had a great response. It was lupron, follistim AND Menopur (which for some reason I felt like made a difference). We got 9 eggs, 6 fertilized and 3 made it to 5 days. I had two excellent blasts transferred, and 1 frozen. My first beta was 977 (on 4wks 2days) then 2893 (4wks 4 days) and then 6278 (4wks 6 days)!! Strong numbers, but I'm still cautiously awaiting my ultrasound at 7 1/2 weeks before getting too excited. I don't know why I had such a better response to round 2 - the thyroid medication, or just the increased meds dosage and adding Menopur, or what, -- but it felt better right from the beginning. Good luck to anyone going through IVF - it is a roller coaster!