Unexplained Infertility & Immunological Issues

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Unexplained Infertility & Immunological Issues

Postby unaffected » Fri Jul 01, 2011 4:09 am

Here is a study I recently came across. I thought the part about 81% of women who had been previously diagnosed with unexplained infertility tested positive for at least one of these immunological issues.

If you have been "diagnosed" with unexplained infertility, and you've been trying for a year or more, I strongly recommend having an immunological blood panel done. It could save you tons of time and money. I wish I had done it sooner.


"Am J Reprod Immunol. 1999 Dec;42(6):335-46.
Immunodiagnostic evaluation in women with reproductive failure.

Kaider AS, Kaider BD, Janowicz PB, Roussev RG.

The Center for Human Reproduction, Chicago, IL 60610, USA.

PROBLEM: Several immunological factors have been associated with diagnostic subpopulations of reproductive failure. It is important to determine a trend of immunological abnormalities among these subpopulations. The purpose of this study is to assist in the selection of treatment for patients suspected of having specific diagnoses of reproductive failure. METHOD OF STUDY: Blood samples from 591 patients were evaluated for the presence of antiphospholipid (APA), antinuclear (ANA), and antithyroid (ATA) antibodies, as well as for lupus anticoagulant (LA), embryotoxic factors (ETF), and elevated levels of natural killer (NK) (CD56+) cells, and all tests were performed as a panel. The patients were grouped into the following diagnostic categories: recurrent pregnancy loss (n = 302), IVF/ET failure (IVFf, n = 122), unexplained infertility (n = 97), ovarian dysfunction (n = 47), and endometriosis (n = 23). The thresholds for positivity and the prevalence of the tested factors among normal healthy populations have been established by testing 100 or more healthy male and female individuals with each one of the tests used (general population control). All tests as panel were performed on 20 normal fertile female individuals as controls (fertile female controls). RESULTS: Of all patients with reproductive failure, 75.6% had at least one abnormal test. The most frequent abnormal result was found to be the elevation of NK (CD56+) cells (37%), followed by ANA (34%), APA (24%), ATA (19%), and ETF (11%). Of the recurrent pregnancy loss patients, 74.2% had at least one positive abnormal result from all of the tests performed: overall, 70% of women with IVF failure had at least one abnormal test; of patients diagnosed with unexplained infertility, approximately 81% had at least one abnormal result; 74.4% of the patients with ovarian dysfunction and 52% of the patients with endometriosis had at least one abnormal result. From normal fertile controls, 10% showed at least one abnormal test result. CONCLUSION: APA, ANA, ATA, ETF, and elevated NK (CD56 ) cells are significantly more prevalent among women experiencing reproductive failure than among the control group and normal healthy individuals.

PMID: 10622463 [PubMed - indexed for MEDLINE]

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Postby AnnaJuly » Fri Jul 01, 2011 11:49 am

That is very interesting. I requested testing for APA and ANA a few years ago. The tests were normal and when I brought my records to a new doctor, she told me the tests did not matter because they could show positive at one time and negative another :dunno: Did anyone ever hear similar? I think she meant sometimes they are activated and others not. I am just wondering whether I was given wrong information.
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Postby unaffected » Fri Jul 01, 2011 12:28 pm

AJ - I'm not sure about that. I tested positive for Antiphospholipid Antibodies recently, but haven't had them tested again. Maybe I will someday just to compare :)

But, the thing w/ immunological issues in regards to infertility is that some doctors don't buy into it. It's really weird, and I wish it were more straightforward.
Me (Kara): 30 DH: 30 ♥
TTC#1 since 2007
:angel2: Jan 2012 - No hb at 9w1d - d&c (Turner Syndrome/Monosomy X)
FET#3 - BFP!
Betas: 8dp6dt/14dpo - 124; 10dp6dt/16dpo - 317; 16dp6dt/22dpo - 6,289; 23dp6dt/29dpo - 32,961
It's a boy!
Henry Marshall arrived on January 9, 2013 (39w2d)
8lbs 5oz, 20"

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Postby AnnaJuly » Mon Jul 04, 2011 11:46 am

unaffected wrote:AJ - I'm not sure about that. I tested positive for Antiphospholipid Antibodies recently, but haven't had them tested again. Maybe I will someday just to compare :)

But, the thing w/ immunological issues in regards to infertility is that some doctors don't buy into it. It's really weird, and I wish it were more straightforward.


Aw babe - if I had a nickel for every doc that totally misdiagnosed and went down the wrong path with me.... :?
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