IVF with PGD (pre implantation genetic diagnosis)

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IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Wed Mar 05, 2014 5:21 pm

Hello ladies,

I am about to embark on my second round of ivf, this time with PGD. In my age group, this technology is giving us a 70% better chance of success at implantation, assuming there are suitable embryos to implant. The main benefit is that we don't waste time transferring chromosomally abnormal embryos which are bound for certain failure. Of course, as with any technology there are also risks, and no guarantees. My last cycle resulted in 3 x five day blastocysts, all of which failed to implant most likely due to chromosomal abnormalities (in my Dr's opinion). And now she has recommended PGD.

Does anyone have experience with this? Successful or otherwise?

:thanx:
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Wed Mar 05, 2014 10:09 pm

Hi Anissa

I am doing multiple cycles of IVFs to bank enough blasts to test for PGD/PGS. I just finished my first cycle and now have 4 snowbabies but I don't know yet if they're normal. Hopefully we get a few normal. Then, we plan to do FET.

GL!
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby hopingandwishing » Wed Mar 05, 2014 10:54 pm

hi annisa,

I havnt started my ivf, hitting some roadblocks, but just wanted to let u know dat if we move forward wit ivf, we will do pgd, bc we had chemical pregnacies... re did genetic testing, and found dh has balanced 3 chromosomes translocation, which my re said he has never seen in his career wit 3 chromosomes, only 2 chromosome... good luck!
me-33 dh-38
ttc- 5/11
cd 3 bloodwork/hsg/sa-cleared
1st iui (4/13)- monitored 50 mg clomid - cd 18 follies under 10mm // cancelled
june 2013 - skipped bc re on vacation
july 2013 - mri found 3 mm cyst in back of pit gland
aug 2013 - moved forward to injectibles (menopur), trigget + iui // cd23 iui 3:00pm - chemical pregnancy
sept 2013- same as aug. protocol... 21x18 and 14x14, triggered and iui 9/28... bfn
oct 2013 - re on vacation/on my own this month.. cd 1 10/15
nov 2013 - cd 1 11/21 same protocol as sept 2013, cd 12 - bfn
(20x16 right ovary) trigger and bd, cd 14 iui - chem preg
12/21 - cd 1 - re on vavation again... grrrrrrrrrr!
jan 2014- ivf consultation // dh - 3 way chromosomes balanced translocation and reduced motility... ivf/pgd and possible icsi
hopingandwishing
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby StephW » Fri Mar 07, 2014 10:41 am

Annisa,
I'm 38 years old & just had my 3rd ER last month. We have done IVF with ICSI & PGD all 3 times. I am very grateful that we did the PGD with all of our cycles, as we had no way to foresee that we'd have a problem with abnormal embryos.
I had polyps in my uterus, but everything else was really good (FSH: 7.6, AMH: 1.46) My hubby has some morphology issues, hence doing ICSI.

1st IVF cycle: 10 embryos. Day 6 ET cancelled because the 4 that were tested came back abnormal, by the next day the other 6 had arrested. Total shock & heartbreak!
2nd IVF cycle: 5 embryos, 2 arrested, 3 tested with PGD, 1 normal embryo that was frozen! :)
3rd IVF cycle: 9 embryos, 6 arrested, 3 tested with PGD & we're still waiting for the results. Unfortunately, where I go if you don't have a fresh transfer you don't get your PGD results for 2 weeks! We should be hearing any day now. Saying LOTS of prayers that we have some good news again!
I definitely feel that the PGD has been a silver lining to this incredibly hard journey. As devastated as we were from the first cycle I know it would've been even worse had I gotten pregnant (for the first time in my life!) and miscarried or later found out there was something very wrong with my baby. My doctor has said that the abnormal embryos are due to my egg quality which is due to my age. She put me on CoQ10 & DHEA, and I get acupuncture done twice a week to help with egg quality.
Anyway, I definitely recommend doing PGD. I wish you the best of luck! :-)
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Fri Mar 07, 2014 6:58 pm

Thanks ladies for your insights,

Adventurer- that's interesting that you can bank embryos. I have to pay per cycle, so the PGD cycle costs the same whether I get one or ten embryos tested. Here's hoping we get more than one.

Hopingandwishing- DH and I are yet to get genetic testing done, that is our next step, blood test coming up. Can you work around the chromosomal abnormality your DH has? Hoping your roadblocks get cleared.

StephW- I can totally empathise with the heartbreak of a failed cycle. I think I had unrealistically high hopes for my first cycle based on my friend's outcomes. We are the same age, went to kindergarten together, used the same fertility clinic, I seemed to have better response to medications, produced more embryos, have a healthier DH (her's is a heavy drinker, overweight and smoked for 20 years). All my hormone levels are great for my age and I am in the correct weight range. Also I have fallen pregnant naturally once which I thought was a positive. However she has had 2 take home babies from 3 cycles. I have had 3 embryo transfers with nada. I should not compare myself with anyone as this process does not seem to make sense. What does make sense is that my embryos must have been abnormal so far, hence going on to PGD. Hey it's great you have one normal frostie!!! That must be such a comfort. I also had a polyp removed a year ago and had a scan last week to make sure it had not grown back. Let us know when you get your PGD results!

Thanks for sharing your stories ladies and I look forward to hearing your updates :babydustg:
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Fri Mar 07, 2014 8:25 pm

Hi Annisa! Are you planning on doing PGS/D on day 3 embies? The lab they're sending our biopsies to in Detroit charge the same for up to 8 embryos, so we are banking blasts. In other words, we are doing multiple IVF cycles without fresh transfer. The risk is that no embies make it to day 5 for biopsy. Maybe your clinic is talking about doing PGS/D at day 3 and then transferring any normals by day 5. In this case the result comes back in 24 hours. In my case (and StephW), once they start testing the results take 2wks to turn around.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Fri Mar 07, 2014 8:36 pm

Maybe I should further explain my rationale in doing multiple back to back so to speak IVF cycles. It's because I want to get as many blasts as possible before my ovaries age. I have diminished ovarian reserve and so I feel my time is running out. I didn't want to do a fresh cycle, get pregnant but lose it in 1st trimester or worse later, and by the time I get around to the 2nd IVF stim, my ovaries are that much older. I wanted to do back to back with no break but my RE convinced me to wait one month. Im not willing to wait 2 tho lol!
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Sat Mar 08, 2014 8:23 pm

Hi Adventurer,
Your plan makes a lot of sense. My clinic does not offer that option. Each cycle is 'stand alone' so to speak. They test on day 5 with trophectoderm cells, not on day 3. All testing is done in house, not sent away to another lab. And I think all embryos are frozen. Also we can not have multiple embryo transfers, only one at a time. We're in Australia where these things are heavily regulated.
I am a little confused about how all of this is going to work as I have not had my interviews for commencement of this cycle yet. These are in a week and a half. But yesterday a nurse rang and asked me to start the bcp so we can get moving even before the cycle officially starts. I thought this was nice of her and very proactive. We haven't even paid yet. But seeing as we are existing clients and have not caused them any dramas, have not been ultra demanding, they seem to go out of their way for us. Which is great.
So you start again in April? How many embies do you transfer at once?
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Sat Mar 08, 2014 8:55 pm

I find it hard to believe that day 5/6 embryo banking is not an option for you. All you do is uncouple the stim cycle from the transfers. It is the same amount of work for them. It's just all the transfers are FETs.

We're only planning to put back one at a time. There's no age limit to carrying a child as long as ones healthy.

That's good that they're starting you on the pill now. That sets you up for the cycle to come. That way once your appt comes up, you're all set to go. It seems that you had one fresh blast transfer and 2 frosties with your first cycle. That's very good! Even though none took, I think you have a good chance on your 2nd cycle. You just need that one good egg/embryo and odds are, you will be successful with this next cycle.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby WitchMagpie » Wed Mar 12, 2014 9:54 am

Anissa,

A lady here on TWW that I went through my first IVF cycle with ended up doing PGD after several devestating miscarriages/IVF fails and she is now pregnant with super healthy twins (25 weeks). It turned out her previous failures were genetic issues, so I can't recommend PGD highly enough. It can really make a difference when nothing else seems to work.

Good luck!

Jenn
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby StephW » Wed Mar 12, 2014 12:38 pm

Annisa,
I got my PGD results back yesterday and we have 1 good embryo again! :-)
So, now we have 2 snow babies: our girl is a 6CC & our boy is a 6AB! I am prepping for my frozen transfer, I go in for BW & US tomorrow morning & will hopefully get an idea of when my transfer will be. I also want to discuss with my doctor whether we should transfer 1 or 2. This will be my first transfer, so we're very excited! :-)
What's the latest with you Annisa?
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Wed Mar 12, 2014 7:15 pm

Yay, StephW!!! So excited for you!! Wow,6AB is amazing!!!

I would put back only one at a time. If there are any issues with your lining the first time, you have another chance. I'd start with the 6CC but this is just my opinion.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Thu Mar 13, 2014 2:22 am

:happyforyou: Steph congratulations. That is just fantastic news for you having another normal embryo! I would get only one transferred at a time. Twin pregnancies are much more risky. And also if there is some issue by chance with the uterine environment at transfer, you don't want to put all your eggs in one basket. But this is just my hunch, I am sure your Dr's opinion is going to be a good guide. AFM I am just on the bcp, waiting for our consultations next Thursday in order to officially begin this cycle. Possible egg collection mid April!

And Jenn, thanks for the encouragement. Hoping your cycle is behaving itself for you. Thanks for the very uplifting story about your friend preg with twins after PGD! I'm confident it is the right choice for us at this stage. Shall keep in touch on the May, June board too :D
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby StephW » Thu Mar 13, 2014 12:40 pm

Annisa & Adventurer,

Went in for BW & US this morning, all went well. I am continuing the Estrace & go back in again on Sunday morning.
I found out from my doctor that we will only be able to transfer 1 embryo since my 2 embryos are from different cycles. She recommended transferring the 6AB (our boy) but said the final decision is up to me and my husband and she'd be fine with transferring either.
So, we decided to transfer our girl (6CC). The transfer will be sometime at the end of next week! We are very excited, nervous too but mostly excited! :-)
Annisa,
Keep us updated on your cycle! :-)
Adventurer,
Did you get your PGD results yet? Keep us posted! :-)
StephW
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Mon Mar 17, 2014 11:21 pm

Hi Steph, any news? When is your transfer? Very excited for you!

Adventurer, do you have any results? Fingers crossed.

I have nothing to report, find out my schedule on Thursday.
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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