IVF with PGD (pre implantation genetic diagnosis)

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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby hopingandwishing » Mon Apr 28, 2014 2:22 pm

hi ladies,

all-gl wit the transfer!

annisa! hope there are at least two normal embies...

adventurer- great news, 13 fertilized!!!!!!!! ur odds r great!

afm, im going to take a mental break, im mentally drained... so.this website doesnt reallu help!!!!!!

wish u the ladies the best!!!!!
me-33 dh-38
ttc- 5/11
cd 3 bloodwork/hsg/sa-cleared
1st iui (4/13)- monitored 50 mg clomid - cd 18 follies under 10mm // cancelled
june 2013 - skipped bc re on vacation
july 2013 - mri found 3 mm cyst in back of pit gland
aug 2013 - moved forward to injectibles (menopur), trigget + iui // cd23 iui 3:00pm - chemical pregnancy
sept 2013- same as aug. protocol... 21x18 and 14x14, triggered and iui 9/28... bfn
oct 2013 - re on vacation/on my own this month.. cd 1 10/15
nov 2013 - cd 1 11/21 same protocol as sept 2013, cd 12 - bfn
(20x16 right ovary) trigger and bd, cd 14 iui - chem preg
12/21 - cd 1 - re on vavation again... grrrrrrrrrr!
jan 2014- ivf consultation // dh - 3 way chromosomes balanced translocation and reduced motility... ivf/pgd and possible icsi
hopingandwishing
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Mon Apr 28, 2014 8:05 pm

Adventurer, that is such good news, all still growing! Many of my 12 had fallen well behind by day 3. And regards PGD, I know what you mean. It is such an expensive process with no guarantees. And the person taking the biopsies needs to be technically competant. My embryologist said the biopsies she got on day 5 (3 were biopsied day 5) may not have been big enough for the DNA to amplify sufficiently. And I'm thinking 'then why the f.... are we doing this? The whole point here is to know what we're transferring back....' Grrr. So I'm kinda expecting what happened to you last time, some 'no result' embies. Hopefully the 2 she biopsied on day 6 are going to get a clear result. But then again, day 5 embies are slightly better than day 6 embies so I may not get results on my strongest embies. Then which ones do I transfer??? If you end up with lots of embies, what will you do? I guess just transfer one or two at a time until you get success? I know a girl who had 18 embies. She has two daughters out of it but she went through many failed transfers along the way. I have been through 3 failed transfers and wanted to avoid too many more of these by doing PGD. Because they are devastating.... Oh well, let's have fingers crossed that we get lucky very soon. Looking forward to hearing how your embies progress.

And Hoping, know what you mean, I have had to stay away from these websites from time to time just to get that mental break. I hope you feel recharged soon.
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Sat May 03, 2014 9:01 pm

All, how you doin? Have you ovulated yet? Transfer coming up?

Hi Adventurer, I caught up with your news on the March thread, congrats, 5 is a good number (same as me). What do you think you will do next? Transfer or stim again?

AFM, still waiting on results...
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Sun May 04, 2014 11:07 am

Hi Annisa! Thanks for checking up!
I'm still waiting to ovulate. Went for bw and us yesterday and today trying to catch it. I go back in tomorrow. If everything is right on time, I should ovulate tonight or tomorrow.

I was super paranoid about missing it so I used first response opk and also the cheapies. And it kept telling me no. So I went and read the reviews the other night and they were horrible! So the next day I went and bought the Clear Blue Easy opk and right away it said I was at my peak! How crazy is that for timing?! So grateful my angels were lookin out because the first response is still saying no. Smh..

Just wanted to tell you all for when your in this part of everything you'll be ready!! :)

Annisa how is your wait going? You should be getting results soon!
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Sun May 04, 2014 11:21 pm

How exciting All!!!
You will be transferring in no time!
Thanks for the heads up about the opk's. When I gear up for a FET I don't actually use them as I get daily blood work. But I have been using ovuplan opk's this cycle as I am not having a transfer until June. I have a clear blue digi in the cupboard but no sticks to go with it. Please let us know when you transfer and how many. I'll be sending positive thoughts your way.

We are still waiting on our PGD results! Hopefully they should not be any longer than another week. It's stressful as you know. I go from hopeful to reserved about it because I do not want to feel too devastated if we get no normals. We are hoping for two and crossing fingers.
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Mon May 05, 2014 8:00 am

Hello: just realized I haven't posted here in a while.

All: can't wait till you transfer those perfect babies back!

Annisa: poor you, waiting for so long! I hope the results come back earlier for you. I'm keeping everything crossed for you that you get results (and good ones) on all your blasts!

AFM: we got 5 blasts in the end for freezing. Also 3 on day 5 and 2 on day 6! Like you said, day 5 is better than day 6 so we have two good quality ones out of this cycle. Our 4BA is good but a day 6. We are going ahead with additional cycles before we transfer. If your friend got 2 out of 18, then I'm willing to go through half as many transfers to get one!!!
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Mon May 05, 2014 6:53 pm

Adventurer 5 blasts to freeze is great!! When do you think you guys will transfer? Idk how you have the patience to wait. Eeekkkk!!

Annisa you might even get a surprise and get your results before you thought. I've been the same as you over this past couple weeks. Tried to put it out of my mind as not to drive myself crazy. That didn't work very well lol because soon as I thought of them I'd start obsessing again. Geez!!

Thankfully things are starting to roll again.. I'll be transferring end of this week or first thing next week.
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Thu May 08, 2014 8:44 am

Hi All: how are things progressing? You must be getting very close to transfer!!

Annisa: I'm waiting on those results just as much as you are! We have the same number of blasts from more or less the same number of eggs... :wink:

AFM: not transferring yet. 2 more fresh cycles and then starting transfer. Too scared to enter the 2ww!! :roll: AF came yesterday so this month is a rest cycle.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Thu May 08, 2014 11:46 am

Hi Adventurer! Don't be scared of the tww mama!! You gotta get through it to get to the end result. Just keep your eye on the prize and know it's coming! Your doing a great job getting through those cycles! That in itself is a huge feet. I know your healthy baby is in there! :)


Annisa I'm on pins and needles waiting for your results. Sending positive vibes and keeping our fingers crossed for you!


I will be transferring Sunday.. Yes Mothers Day. I first thought, oh the irony of it all lol but I'll just take that as a good sign from my angels that this is it for me. Wish me luck! :)
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Thu May 08, 2014 1:52 pm

Thank for your encouraging words All! :kiss: Yay!!! A transfer on Mother's day! How appropriate! I agree that this is a very good sign :)
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Fri May 09, 2014 4:25 am

Wow, All, thinking of you and hoping everything goes well with your transfer on Sunday. I agree it is a good sign to be transferring on Mother's day! Can't wait to see your BFP! I hope your TWW is not too difficult.

Adventurer, so two more stims for you. That's 4 in total? You are a tough cookie. I found my last stim very physically demanding with the bloating and pain for nearly 2 weeks afterwards. That's because so many eggs were collected. You will have lots of embryos banked by the time you transfer. Just wondering how you will know which ones to transfer? Will you base it on grading? You should definitely get a baby out of this after 4 cycles! Have you decided whether to stay at the same clinic?

AFM, I sound like a broken record, still waiting on my results......3 week mark coming up. They will be getting a phone call from me on Monday!
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Tue May 13, 2014 11:42 am

Hello Ladies!

Just checking in.. Wondering how everyone is doing!

Annisa any results yet??

Had my transfer Sunday and it went perfect! She said she couldn't of hoped for a better transfer so I'm def keeping my fingers crossed.

I swear I can feel things happening here and there but who really knows?! I feel positive.. With the occasional doubt. When you don't feel anything, that's when you wonder if there's anything going on in there at all. I'm def on the roller coaster called the tww.


Testing out my trigger still of course so we'll see.. :roll:
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Tue May 13, 2014 1:11 pm

All: Congrats on being PUPO (pregnant until proven otherwise)!!! :D You have a great chance! I don't envy you being in the tww. I'm so scared of the tww lol - I'd rather brew eggs lolol

Annisa: Poor you, waiting thing long!! Did you get to talk to your office?

AFM: I'm on for the June cycle. My FSH is highish again at 10.2 :( The next cycle will be done at the same clinic. Thinking of going to Dr. Sher in Las Vegas but I am unable to take vacation during that time since all the vacation has been booked off at my workplace. If I manage to go, I'll have to do a lot of switching at work to try to get a week and a half off.

Met with RE again this morning. The whole 'no result' thing got resurrected and RE said something that got me worried again. Ugh!! She said that it seemed what Genesis was telling me and what Genesis was telling their Lab were not the same!! Now I'm feeling uncertain again and not liking it! I have to bug Genesis again to clarify things once and for all.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Tue May 13, 2014 10:20 pm

Hi All, Thinking of you during your TWW, it is the hardest part of this whole process! Will you POAS?

Adventurer, I hope you can clear the air with your lab re the 'no result' embryos. The decision to do PGD can have great benefits, but as with all of this journey, no guarantees. Maybe sending your next batch to a different lab is an option? Or is it the skill of the embryologist actually taking the biopsies that concerns you?

AFM, FINALLY!!! We received great news today. We have ONE normal embryo! And it was one of the day 5 embryos. The remaining 4 had a range of monosomies and trisomies. I know I had hoped for 2 but still I am over the moon with one. It could have been so much worse at my age! Now we know there are no guarantees that this one will stick but it has a great chance and we are optimistic. Add it is a beautiful sunny day outside. I just need to bask in this good news for a while after such a long period of uncertainty. We plan to transfer in June. PGD has been totally worth it for us. Now, we can avoid having to go through multiple unsuccessful transfers, which was our whole reason for doing PGD. :fingersx:
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Wed May 14, 2014 6:25 am

I know I said so on the other thread, but I'll say it again here! :happyforyou:

I'm jealous. I wish we had the same success with PGS that you did. :?
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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