IVF with PGD (pre implantation genetic diagnosis)

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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Wed May 14, 2014 2:04 pm

Sorry ladies but.... (disclaimer: rant follows, read at own discretion :wink: )

Begin rant// I am so f'ing annoyed by my RE about this whole 'no result' thing. During my meet with RE yesterday she mentioned that DNA is not amplified by polymerase chain reaction (PCR) during microarray CGH. I was thinking, what the??? I had to look it up on the Internet to confirm that it is (it's a variation on the theme of PCR). The thing is, I work in laboratory medicine and happen to know that PCR is the main DNA/RNA amplification tool used these days. RE suggested that I was overstepping my bounds and that this was not my area of expertise but in fact it is... Any DNA test nowadays begins with PCR, otherwise there isn't enough DNA to do the test! GR! :mad: //end rant

Thanks for listening/reading. I just had to get that off my chest.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Wed May 14, 2014 7:11 pm

My goodness!! I wrote a whole book and don't know where it went! :x


Yayyyyy!!! Annisa!! That is amazing!! And that news was totally worth the wait! All you need is 1 :D
June will be here before you know it and we'll all be obsessing with you.

Adventurer, what the heck is going on with those people?! It's like they don't understand what a big deal it is.
We are literally trusting our children's lives in their hands. I feel like they're getting things mixed up too often.
I hope everything turned out ok n the end and if you have the time to go to Dr Sher.. he seems like he really knows what's up. I enjoy reading his blog a lot. He always has an answer that sounds correct. KUP


AFM... I'm just chillin. Having some little signs, taking note but not reading into it too much. Definitely feeling things moving around in there a bit. Yesterday I was sitting down and got shaky and felt faint with nausea off and on all day. A few other things too plus I had a little pink on the toilet paper today.

IDK.. I guess we'll see. I'm still testing trigger out. It lightened up today. Hopefully it doesn't go all the way away and just starts getting darker. :D
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Wed May 14, 2014 10:52 pm

All, you seem to be handling this TWW like a pro. I think I will have to make a huge effort to remain as calm as you are. Can't wait to hear your news when that BFP arrives!!!!

Adventurer, I can relate to how you are feeling and the rant is warranted. Just a couple of days ago we had no idea what our results were going to be, but the main thing I would have been pissed off about would have been 'no result'. Such a f... up by your lab or the person who collected the cells. They really know how to cover their own arses as well. We were warned that the DNA may not amplify etc. And even with our one normal embryo they can only say it is normal to 95% certainty. Ivf has got to be one of the only areas in life that I have yet faced, where the effort you put in does not equal the reward. Sux when the professionals keep messing things up for you. Your Dr. was just being arrogant when she asked you to confine yourself to the area of your own expertise because she felt threatened by your level of knowledge I reckon. If I were you I would switch clinics ASAP.

AFM, now another, less stressful period of waiting. Probably just under 2 weeks til af and then we start monitoring my cycle with blood work in order to pick the right date for our FET. DH and I are pretty happy at the moment. Nothing much we can do now other than enjoy the next few weeks.
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Thu May 15, 2014 9:16 am

Hi lovely ladies!

Thank you so much for letting me vent and being so supportive. Annisa, I'd love to switch REs but it would mean a probable delay in our plans and with my bloods being borderline and my AFC low I don't want to take the risk. She is still an expert in the field of infertility, just not PGS or apparently anything to do with laboratory medicine and techniques. :roll: I am not impressed with the stuff that comes out of her mouth sometimes but we are planning on doing just one more with her. Then hopefully we will try one with Dr. Sher in Vegas.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Fri May 16, 2014 12:08 pm

I'm thinking I got my bfp :)

Not for sure so I'm not telling anyone yet. I'm a little confused because of the trigger. It should be almost gone by now. On 3dp5dt it was considerably lighter and got darker the next morning & PM. It's gotten a tiny bit darker today too. So I'm assuming my trigger is still fading but my bean is taking over. :yay:



I'm not gonna go crazy until I see the tests from the next couple days though. My blood test will be Tuesday.
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Fri May 16, 2014 2:36 pm

Yay - All!!!! I have a great feeling about you!!! That and also the fact that you have a greater than 70% chance of success :D
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Fri May 16, 2014 6:18 pm

:babyg: This is it All!!!! How exciting! This has to be your BFP. And how amazing that you already know it's a girl. You're giving me a lot of confidence here.
Please keep us posted!
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Fri May 16, 2014 8:59 pm

Thank you Adventurer!! :)

Annisa I forgot to ask what yours is.. A boy or a girl? Sorry if you
posted that already, I missed it.
That was one of the coolest parts of this whole situation.
Just because, your baby's not an it. It's a boy or it's a girl and you can
address him or her as such. It feels really good to be able to do that.
Especially if your crazy like me and you like to talk to it already lol!!
Everything you do is just so much more fun knowing they're with you.
Even if it is just a ball of cells. :mrgreen:
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Sat May 17, 2014 12:37 am

All, actually when the embryologist called me with the news she didn't say what sex the embryo was. It was only a couple of days later that I started wondering about it. How I race ahead of my self, making lists of names like a loony! I think I will give the lab a call and ask. But I am not sure if they are legally allowed to tell me.
Anyhow, I'm so excited for you!
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Sun May 18, 2014 8:32 pm

Thinking of you All and crossing fingers that you're getting some really good positive pee sticks over there! Any updates?

How are you Adventurer?
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Mon May 19, 2014 9:09 am

Hi Annisa!

I thought I had responded back to you about your last post.
I don't see why the lab wouldn't be able to give you
all the info about your embryo. But in my case it was my Dr
who called to tell me. She didn't tell me either, we were getting off
the phone and I asked. I think it's adorable that you already got a lost of names :)



AFM.. My blood test is tomorrow. Can't wait to hear my beta because my tests are blazin!! They got a little lighter on 2dp & 3dp and then just got darker ever since. Today I'm 8dp5dt and both lines on the tests are the same in darkness. I'm wondering what all I have going on in there lol..
We only transferred 1 so we'll see... I'm still nervous. I'll feel better hopefully when I see good betas this week. :belly:
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Mon May 19, 2014 4:33 pm

all: :happyforyou: congrats on your BFP!!!! You give me hope!
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby AllontheTable » Tue May 20, 2014 4:06 pm

Thank you Adventurer!

Any update Annisa?

I can't wait until you ladies start your cycles! I'll be here
obsessing with you and rooting you on for sure! If I can get knocked up, you def can Hahahaa! :wave:


Got my beta today and it's 223. Eeeekkk!!! :happyforyou:
I know we got a long way to go but I'm just enjoying
everything in the now. So happy!
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Annisa72 » Tue May 20, 2014 8:38 pm

Way to go All!!!!!
:wave:
This is so great! Wow and your beta is a really high number!
Congratulations, you must feel so excited. Enjoy every moment!

AFM, just waiting for af. And at 5 dpo we will transfer our embie. From memory, the next cycle after a stim, af is usually a few days late. Is that usually the case for you Adventurer?
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: IVF with PGD (pre implantation genetic diagnosis)

Postby Adventurer » Wed May 21, 2014 6:26 am

Congrats All!! I had no doubt that your beta would be great esp if you met the control 8dpt! I hope to be where you are someday.

Annisa: you're next!!! Yes, my March cycle was a week late. I expect this cycle to go the same.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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