IVF canceled due to high progrsterone - anyone else?!

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IVF canceled due to high progrsterone - anyone else?!

Postby AndyandAndy » Sat Nov 29, 2014 10:26 pm

I'm so frustrated and disappointed! My 7th cycle ..2nd attempt at IVF, was completely canceled today bc my progesterone was 4...I'm in the stimulating phase, taking micrdose lupron AND 4 bravelle + 4 menopur per day for the past 7 days..and now they suspect that I ovulated on my own a little over a week ago and my ovaries havent completely suppressed before starting this round.
But wouldn't they have known that in my initial blood draw and scan before giving me the green light?!
And now they said I may not get AF for 35 days? (I'm regular every 28 days)...
So what happens with the follies that have already started growing? I have 5-6 of them...is there even a possibility of ovulating them and trying for a natural???
Me: Andrea,40
DH: Andrew, 29
DD: Lexy,17
Unexplained fertility since 2003
12/2006 - 1st rd Clomid (w/ex dh)= BFN
2/2007- 2nd rd Clomid+HCG trigger=BFP
4/2007- mc at 9 weeks
9/2013 - laproscopy 4 ends
11/20/2013 - 1sr rd of Letrazole canceled on day 2 bc of cysts on ovaries. 2 weeks of BCP's
12/9 - Letrazole 2.5mg 2's/day cd 2-6 / Bravelle 75iu cd 6-10 / Ovidrel trigger shot
12/310/2013 - BFN
3/2014 - letrazole+Bravelle+ trigger
3/2014 - BFN
5/2014 - same as rounds 2-3 but w/ IUI instead - BFN
7/2014 - same as prev rounds also w/IUI - BFN
9/2014 - first IVF, Bcp's for 2 weeks, bravelle/menopur 75iu ganilrelix, only had 3 follies, cycle converted to IUI
10/11/2014 - BFP!!!!
10/13/2014 - BFN - chemical pg =(
11/20/2014 - started round 7 - bcp's day 1-6 microdose lupron+bravelle+menopur
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Re: IVF canceled due to high progrsterone - anyone else?!

Postby Sunshinetex » Sun Nov 30, 2014 4:30 am

Andrea....so sorry to hear that. I would try, but if you already ovulated, then those other eggs will probably be re absorbed into the body. However, it is possible to ovulate twice in a month, so you never know. Get to bd! If it doesn't work, we will be cycle buddies. I am starting bcp in mid December for Jan er. Fx!
Me - 41
BF - 39
TTC #1 - Sept 2012

Hsg October 2014 - blocked tube. Straight to ivf
Ivf #1 - feb 2015 - bfn
Ivf #2 -may 2015 -
5/7 - 10 eggs retrieved, 9 fertilized
5/12 - et. 5 day transfer - 1 blastocyst and 2 morulas - bfn
7/2 - surgery to remove/repair tubes - tubes cauterized
Ivf #3 - sept 2015
9/10 - 13 eggs retrieved, 10 fertilized
9/15 - et 5 day transfer 3 blastocysts....
9/24 beta 152 9dp5dt
9/28 2nd beta 248 13 dp5dt
9/30 beta #3 468 15dp5dt
10/3 beta #4 1672 18dp5dt
10/9 u/s 1 baby
10/19 u/s 1 baby with heartbeat of 140. Due June 3, 2016.
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Re: IVF canceled due to high progrsterone - anyone else?!

Postby Adventurer » Sun Nov 30, 2014 8:50 pm

I'm sorry, Andrea. :( sunshine is right, if the progesterone is 4 it is either a sign of premature ovulation or premature luteinization, ie. your pituitary gland was not adequately suppressed and your LH surged high enough to cause your progesterone to rise. Were you on Microdose Lupron antagonist protocol? If so, the antagonist should be started once the E2 reaches 250 or you risk an early rise in progesterone. 4.0 is high enough to warrant cancelation unfortunately because the egg quality would have been adversely affected.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF canceled due to high progrsterone - anyone else?!

Postby AndyandAndy » Wed Dec 03, 2014 7:26 am

Yes I was ok the microcode lupron flare protocol.
Also, I was on bcp's for only 6 days prior to starting injections unfortunately the 6 days wasn't enough to suppress the ovaries and I actually ovulated on the 6th day...AND DH and I didn't bd BC I was not feeling well due to the injections ..oh the irony pffft!
Me: Andrea,40
DH: Andrew, 29
DD: Lexy,17
Unexplained fertility since 2003
12/2006 - 1st rd Clomid (w/ex dh)= BFN
2/2007- 2nd rd Clomid+HCG trigger=BFP
4/2007- mc at 9 weeks
9/2013 - laproscopy 4 ends
11/20/2013 - 1sr rd of Letrazole canceled on day 2 bc of cysts on ovaries. 2 weeks of BCP's
12/9 - Letrazole 2.5mg 2's/day cd 2-6 / Bravelle 75iu cd 6-10 / Ovidrel trigger shot
12/310/2013 - BFN
3/2014 - letrazole+Bravelle+ trigger
3/2014 - BFN
5/2014 - same as rounds 2-3 but w/ IUI instead - BFN
7/2014 - same as prev rounds also w/IUI - BFN
9/2014 - first IVF, Bcp's for 2 weeks, bravelle/menopur 75iu ganilrelix, only had 3 follies, cycle converted to IUI
10/11/2014 - BFP!!!!
10/13/2014 - BFN - chemical pg =(
11/20/2014 - started round 7 - bcp's day 1-6 microdose lupron+bravelle+menopur
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Re: IVF canceled due to high progrsterone - anyone else?!

Postby Reapage » Wed Dec 03, 2014 1:23 pm

Oh Andrea- I am so sorry to hear this... Ugh this is so awful!!! The IVF process is soooo up and down. Hopefully you will get your period in less than 35 days and you can start again!!! Keep the faith, I know its so hard right now.
Me: 24, PCOS, on Metformin 2000 daily
Him: 33, low count, low motility, 0-1% morphology
TTC #1 since Sept 13.

IVF#1 Antagonist protocol
ET: one BA Expanded Blast, Froze one AB blast.
MC confirmed
IVF #2 FET
BFN

IVF #3 Luteal Phase Lupron Protocol
ET 1 4AB blast & 1 4BB blast
1 BA blast made it to freeze
BFP!
12dp5dt beta=738
15dp5dt beta =1,979
17dp5dt beta = 4,029

FIRST U/S @6W2D SHOWS TWINS!!!!
Baby A :hb: 128
Baby B :hb: 112
SECOND U/S @7W2D TWINS ARE PERFECT!
Baby A :hb: 166
Baby B :hb: 151

ITS A BOY AND A GIRL! :babyb: :babyg: :balloons:
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Re: IVF canceled due to high progrsterone - anyone else?!

Postby Adventurer » Wed Dec 03, 2014 4:14 pm

Andrea, I really hope you don't mind me mentioning this but it wasn't because your ovaries weren't suppressed enough by the BCPs, it's because the ganirelix wasn't given soon enough and/or your LH was allowed to get too high (11 is high in an IVF cycle). The BCPs are given to reduce the effect of LH/testosterone on your developing follicles, not to 'suppress the ovaries'. It does keep the antral follicles nice and small so that they hopefully grow together during a stimulation cycle. Given that the microdose lupron protocol purposely causes an early LH surge (plus FSH which is really why it's used and why it's also called the microdose flare protocol), I would recommend avoiding this protocol next time. It works just as well (similar to a microdose flare) to administer a higher dose of FSH for the first 2 days of your cycle, which is what my current RE, Dr. Sher does. I took 450 IU Gonal-F for the first 2 days and then dropped down to 300 IU Gonal for the rest of the stim. Dr. Sher also likes to use Menopur sparingly in older women like us and I began a daily half dose of Cetrotide (he also uses half dose Ganirelix) on day 3 of stims. He didn't even monitor my LH or Progesterone throughout this cycle because the protocol is designed to keep both of these low. I had the best cycle out of 4 cycles (see my siggie). Best of luck!
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF canceled due to high progrsterone - anyone else?!

Postby Adventurer » Wed Dec 03, 2014 4:18 pm

Oh I should also mention that I was on BCP for a month and then Lupron for 7 days before switching to Cetrotide. Then didn't start stims until day 5 after my switch to Cetrotide. I did Dr. Sher's agonist/antagonist protocol and it worked brilliantly for me. Another lady from this forum is with Dr. Sher now and his protocol is so far working great for her too.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: IVF canceled due to high progrsterone - anyone else?!

Postby mrselaine » Sun May 24, 2015 1:03 pm

hi all new here i stumbled across this forum because i am in the middle of ivf and experiencing this raised progesterone problem too. not really sure what to do but seeking support. I'm guessing it's because of the protocol (late antagonist).

Adventurer - i can see that you were successful with your 4th IVF with a protocol change. I'd love to pm you if I can work out how!
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