3 or more failed ivf stim cycles

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3 or more failed ivf stim cycles

Postby Annisa72 » Fri Dec 26, 2014 8:01 pm

Hi everyone,
I saw on another website, a thread for ladies who had 3 or more failed stim cycles behind them. The thread has been active for a couple of years and I thought it would be a nice idea to have a thread like that here.
This is not to say that first timers do not experience stress or disappointment, it's just that repeated failures add a new dimension to the ivf journey and have a massive impact on our lives in many ways.
I will be commencing my 5th stim cycle in January.
Anybody in a similar situation?
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Wed Jan 07, 2015 1:25 am

Hi Annisa,
This is my first post here but have been reading this forum for the last 2-3yrs, sad I know, but it has helped with my own situation and to figure out where to next.
I'm hoping my info below can show where we are at with our ivf journey.
Just today we went in to sign our consents, get some meds and discuss our protocol for our 3rd fresh cycle. We have been lucky enough to have 6 transfers and 3 pregnancies from two fresh cycles, however, unlucky to have no baby as a result.
I have my 5th (or is it 6th I can't remember!) Lap end of jan with the fresh cycle following in feb. After our last loss @10wks the only thing we have changed is increasing steroids and clexane. Specialist is at a loss as to "why" we keep miscarrying. Which is frustrating to say the least.

I agree with your idea that having more than one stim cycle does add to the ivf journey, as ultimately this is our last resort and how many times can one keep setting themselves up INTENTIONALLY for such heartbreak. We haven't committed fully yo the surgery as yet or the 3rd fresh cycle,, over the next week we have to make out minds up. May just flip a coin ;-)

Have you started your cycle as yet? I see your in Australia, as am I!
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
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Re: 3 or more failed ivf stim cycles

Postby Annisa72 » Mon Mar 16, 2015 10:56 pm

Hi Roar,
I'm so sorry to take so long to get back to this thread, when I first started it, I was disappointed at getting no responses so after a while I went off and joined an Australian based forum. I can see you are Australian too! How did you go with your last cycle? Or are you doing it this month?

I had eggs collected in January then had PGD. I got 3 to blastocyst stage, 2 came back abnormal and one came back 'unknown'. I was really annoyed about the 'unknown' because I experienced delays and paid extra for PGD. Now we have to go through the torture of transferring this unknown embryo just before Easter. Have booked a second opinion consult for end of April. It would be nice if the second opinion is not needed.

I will log on here again soon to check on you. If you would like to join the bubhub it is an Australian based forum. The advantage is being in the same time zone with most of the other ladies. Also we all have the same health system to deal with, completely different to the US. I have a different name over there but should be recognisable by a similar siggy.
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: 3 or more failed ivf stim cycles

Postby Adventurer » Tue Mar 17, 2015 10:32 pm

Annisa, I've wondering about you. I'm crossing everything that this embie is your take home baby!! xx
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Tue Mar 17, 2015 11:31 pm

Hi Annisa,
No worries with the response. I figured as much,, different time zones is always difficult.
It would have been very frustrating having done PGD and not getting a good solid reliable answer,, 'unknown' to describe an embryo can make you have such varying thoughts,, from the extreme of this could be it to its never going to work,, ugh the life of Living IVF.

We boarded on getting a second opinion for our next cycle but our specialist has been amazing in suggesting some new things (trying a different embryo culture - EmbryoGen & of course upping meds). I have also had a two lots of surgery to correct my septum (3rd time lucky!) so we are still paused! I'm finishing off my esteogen (progynova) and progesterone (provera) today which will start me on day 1 by the weekend. I'll have a much needed and wanted drug free cycle off (trying natural yay!!) then will go ahead with the 3rd fresh.

I'd love to join an oz based forum,, I'll google bubhub Australia and see where that leads me.
I wish you all the best for your Easter transfer, I find it becomes so hard to be optimistic when it becomes all about stats, facts, grades, number,,, but thinking positively always helps the mindset,, I need to listen to myself here as I'm quite the realist (some say pessimistic I say I'm all about facts!) ,, good luck and as my husband keeps saying it's got to be our turn soon,,, so I do hope and wish it's yours

May see you on the hub!! ;-)
Roar

.
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
Roar79
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Re: 3 or more failed ivf stim cycles

Postby Hope2015 » Wed Mar 18, 2015 4:42 am

Hi ivf'ers,

Im aussie and have had 3 ivf cycles. Im on the 4th right now and had EC today.

I have had increased eggs produced as I go along but no positives as yet. Embryos arent sticking!

All the best on your next cycle whether natural or IVF.
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Re: 3 or more failed ivf stim cycles

Postby Annisa72 » Thu Mar 19, 2015 12:11 am

Thanks Roar, enjoy the much deserved drug free month. You are right about the positive attitude. I struggle with that after so many cycles. And I also like to think I'm realistic rather than pessimistic. I have up and down days, today is a good day, I've spent plenty of time in the sunshine. Which clinic are you with? It's great your Dr is trying new things.

Adventurer, hi! I am so glad everything is working so well for you. I remember when you went through the 'no result' thing with cgh and how frustrating that was. Well that's what I'm going through now. And my age is creeping up on me, I'm now 42. I really thought it would turn out for me eventually but now I am not so optimistic as I've completed 5 full stims and had one cgh normal but it did not stick. We'll see. I stopped joining the monthly threads here as it was so hard always being the one without a BFP. And to be honest it was upsetting when first timers would whine. I'm finding an over 40's thread on another forum most helpful these days. Make sure you post when your baby arrives as I still try to follow your progress now and then.

Hi hope2015, come and join us on the bub hub in oz. And good luck with this cycle.
Me 41, adenomyosis, endometriosis, blocked left Fallopian tube
DH 39, no problems
TTC since August 2012
Lap March 2013, polyp removed
HSG August 2013, confirmed left tube blocked
Ivf#1; stimulated cycle Oct 2013, fresh embryo transfer, BFN, 2 embies frozen
Naturally occurring BFP 01/01/14, chemical pregnancy
FET Jan '14, BFN
FET Feb '14, BFN
Ivf#2; April 2014, 5 blastocysts, 1 CGH normal embryo transferred June 2014, biochemical miscarriage
Ivf#3; September 2014, one blast sent for CGH testing, abnormal
Ivf#4; November 2014, 7 eggs fertilised.....
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Re: 3 or more failed ivf stim cycles

Postby Hope2015 » Thu Mar 19, 2015 8:39 pm

Hi

Is there a particular thread I can find on Bubhub?

I'm researching https://m.youtube.com/watch?v=wgXuEshmn0w
Gyno and specialist for ivf. Need to find out his cost for a consultation.
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Fri Mar 20, 2015 7:46 am

Hello!!

Annisa - I hear you!!! Celebrate the good days they are few and far between during cycles. I have really enjoyed the off time lately. I always wondered how ivfers didn't just want to do back to can cycles and get things done (this was me once upon a time!) but I can appreciate the drug free cycles and the mental off time. I'm in WA and now have a text msg relationship with my specialist (sad I know but makes me feel loved and not a number!)

Hope- how did the collection go? Transfer date given yet or are you doing a freeze and then FET?? Good luck with it all. Being a seasoned ivfer (do love that word!) I'm sure it's just part of life now. I think once I hit my 4th transfer it lost it's Magic,,

I too can't find the Australian thread on hubbub,,, but to be honest it confuses me,, lots of ads,, I'll give it another try. M
Good luck ladies ,,
Roar
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
Roar79
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Posts: 37
Joined: Mon Dec 09, 2013 5:01 am

Re: 3 or more failed ivf stim cycles

Postby Roar79 » Fri Mar 20, 2015 8:21 am

And i apologise,,,

Congratulations Adventurer,, I think I have been reading your 'story' for awhile now. It's so lovely to see success. I wish you all the best, enjoy your pregnancy it's such a gift :D
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
Roar79
Member
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Posts: 37
Joined: Mon Dec 09, 2013 5:01 am

Re: 3 or more failed ivf stim cycles

Postby Adventurer » Fri Mar 20, 2015 1:46 pm

Thank you so much Roar and Annisa! :kiss:

It's still sinking in slowly that I'm pregnant since I still don't feel anything. Oh well, I don't think I'll completely relax until baby is born and even then... :roll:

Annisa: I completely understand how it's hard to read threads sometimes. I'm so sorry about the CGH no result. So frustrating!! I pray that your embaby takes this time. Please don't give up. I "met" a lady (online) who went to Dr. Sher and stimmed at the same time as me with the same protocol. She's 42 and is pregnant for the first time. I'm praying so hard for you!

Hope: :hi:
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: 3 or more failed ivf stim cycles

Postby Hope2015 » Sat Mar 21, 2015 10:23 pm

Hi there

Wow Adventurer ! Half way there for your pregnancy...
So happy for you

Roar this is /was my 4th. We had a very bad situation last week. My first US showed 10 follicles and it was the same as cycle #3 (i was so relieved and happy)but by the second US I had ovulated and lost all but one. I need to get the BT results to check what levels my bloods were. I felt so stimulated which was a good sign however this Clinic is closed on weekends and I waited 4 days til the monday then that was the craziest day where I had to have another shot to stop ovulation. (This was orgalutran)
Confused whether it was the fault of clinic letting me wait for too long - my ovaries were so sore or the actual drug not working to its best.

I know ivfers understand how the drugs can be, the hormone flunctuations and putting your heart into the cycle.

My Dh has already asked if I have made an appointment for next cycle but im now scared.. I do know ill try again til I get BFP.Iv

Ive been offered counselling for what happened. The one egg they got didnt fertilise well and its now discarded. Im soooo sensitive today, and i dont believe them as last cycle 5 fertilised perfectly. I think they stuffed me around.

im sure ill be better tomorrow.

On a positive note ive researched about losing eggs and that it doesnt affect your egg reserve and that they would normally die anyway. Anyone know if this is correct?

I want to see another FS. ! So im going to save up now.
Our current clinic is free so its very convenient to keep.going there but boy am i annoyed. Dh doesnt want to pay for IVF since we have this one going and he does think it just happened.

:D :omg:

Special ladies thanks for listening !!! :x
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Sun Mar 22, 2015 5:53 am

Hope - that all just sounds so awful. To go through all the prep work of needles etc in the lead up to trigger and collection and then NOT have the results you had hoped for is very frustrating. I have found that no clinic would ever admit to fault as that would start too many questions and legal issues etc,,, sometimes it's best to do some self talk and keep reminding yourself that you can't control this. I have started having some counselling just recently and the best thing she said to me was that I am doing all I can, I have DONE all I can. It was very profound and nice to hear. This now has become my daily mantra. So do tell yourself that, you have done ALL you can with what you have been given. For me it allows me to let go of all the guilt and responsibility. From what I have been lead to believe is losing eggs won't affect your reserve. Don't feel as if you are 'wasting' them if that's what you mean. Yes we only have a certain number we are born with but if your AMH & FSH levels are 'normal' then you needn't worry.

That sounds like a plan,, save for a specialist but in the meantime continue where you are??? A second opinion can be reassuring. It's sweet your DH is keen still, mine is always very supportive and positive, but only when you are ready try and again. In all areas,, physically, emotionally etc.
hope you are feeling better today,, I've been off provera since Wednesday and no sign of my period,,, typical!!
Take care
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
Roar79
Member
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Posts: 37
Joined: Mon Dec 09, 2013 5:01 am

Re: 3 or more failed ivf stim cycles

Postby Rebcat » Sun Mar 22, 2015 9:18 pm

Hi girls, if it is ok, I would like to join you. I used to contribute to these boards a few years ago, but it was just so isolating being the only one left when everyone else eventually got their success. No one knows the emotional pain of IVF unless you have been through it and it is a special kind of hurt having multiple failures and no joy to take the jagged edges off the sad parts.

I have tried so hard over these years and have dug deep to find the strength to carry on, but I know my time is getting short. Every time I say it's the last time, but I think this one really is. I am scared what will happen when it is over though and don't know if I will ever be able to come to terms with not being a mother. I am sad, frustrated, confused and angry at all of this. I maintain a successful outward facing world, but have a hidden world inside my head that constantly plays through all these emotions. As time goes on, it gets harder to keep these worlds apart.

I know that you understand this. It has taken this long for me to feel like I can be part of this again, so thank you for making this board. Xxx
Me 37, DH 39 , TTC#1 since 2009 :(
IVF #1 Oct 2010 - BFN
FET Feb 2011 - BFP, low hcg, m/c
IVF #2 Nov 2011 - BFN
IVF #3 Apr 2012 - BFN
IVF #4 2013 -BFN
IVF #5 2014 -BFN
Donor IUI x 4 2014 - BFN x 4
IVF #6, July 2015 - shocking BFP!
HCG day 14 - 150
HCG day 17 - 800
Waiting for 7 week scan
It's twins... can't believe it.
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Mon Mar 23, 2015 7:24 am

Hi Rebcat, I have never read a post before that I felt so familiar to! I have only just started posting but have been reading for many years (sad I know!) but it does get difficult to read @ times. My specialist once told me I shld have had a baby by now,, that hurt!

I too feel time isn't on my side in regards to age, FSH, career and marriage. Nothing helps a marriage out by wanting a child but yet barely even being able to be intimate together!! With the drugs, surgeries, egg collections, internal ultrasounds, etc,, makes it difficult! I too am scared of the next year (our last time!) and wonder how I will deal with a result that I don't want. My counselling is helping though.
Anger doesn't even cover the emotions does it??? Unfair,, that's my thing,, I've always thought your work hard and you can achieve anything,, not in this area.

I feel I have been very negative so far so,, let's be positive and have a positive mindset!! One more try, one more egg collection, one more trigger, one more,,, and why not??? Why can't it be our time??? We can do this!!!! :D
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
Roar79
Member
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Posts: 37
Joined: Mon Dec 09, 2013 5:01 am

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