3 or more failed ivf stim cycles

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Re: 3 or more failed ivf stim cycles

Postby Rebcat » Tue Mar 24, 2015 2:11 am

Hi Roar and others. Thank you for replying to my post, I can relate to everything you said - at least we are not alone here! You are so right, we wouldn't still be doing this if we didn't still hang onto hope. What will be, will be, so we may as well be positive until proven otherwise :)

So I have a question for everyone - after multiple unsuccessful ivf cycles, what protocol are you being recommended/doing? Sorry if I don't have the terminology right and I may be talking different drug names, but I have tried a regular long stim cycle, the same again but with double stim dose... oh it's been so long, I think puregon + buserelin? Then a cycle with cetrotide, then one with testosterone patch, there must have been others in there too. Basically none seemed to produce more follicles than others - I usually get around 8-12. So my Dr is debating what protocol to put me on for my upcoming cycle. Would be really interested to hear what others are doing.
Me 37, DH 39 , TTC#1 since 2009 :(
IVF #1 Oct 2010 - BFN
FET Feb 2011 - BFP, low hcg, m/c
IVF #2 Nov 2011 - BFN
IVF #3 Apr 2012 - BFN
IVF #4 2013 -BFN
IVF #5 2014 -BFN
Donor IUI x 4 2014 - BFN x 4
IVF #6, July 2015 - shocking BFP!
HCG day 14 - 150
HCG day 17 - 800
Waiting for 7 week scan
It's twins... can't believe it.
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Re: 3 or more failed ivf stim cycles

Postby Adventurer » Tue Mar 24, 2015 6:39 am

Hi Rebcat: I may be able to help but I need to know what your most recent day 3 FSH, LH, estrogen and progesterone are, plus your most recent AMH. In other words, I need to know whether or not you have DOR. For my first 3 cycles, I did the antagonist protocol (with cetrotide) but for my 4th and final IVF, I went with Dr. Sher and did his agonist/antagonist conversion protocol (a long protocol) at reasonably high doses of Gonal F. It was by far my best cycle (and with lowest AFC of 8!): I got 33 eggs and out of 22 fertilized with ICSI, 12 made it to blast. I had 5 CGH normals out of that batch. I was also doing acupuncture which I believed helped a lot.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: 3 or more failed ivf stim cycles

Postby Herman2 » Tue Mar 24, 2015 2:25 pm

Hi ladies,
I'd love to jump on this thread. I'm starting my 3rd IVF stim and all the other forums are just not in line with my experience. I'm not new to this and love the support here for the rest of us That have been on this road for a while.

I've been TTC for a decade. I'm 38. Started all the infertility work in 2006 and 2007, moved/new job, started again in early 2009 w/2 failed IUIs, then in Nov '09 a successful IVF, and a beautiful daughter, born Aug '10.

We started trying immediately...moved/new job again (we are military). No luck and a failed IVF in Aug'13. It's taken us until now to recover financially, and so I'm starting my injectables and have a retrieval scheduled for Early April. We opted for genetic testing but none of our blasts have lasted passed 3 days, never able to freeze any either so we are preparing for a 3 day transfer again without the testing. I'm so grateful for the success we had in 2010, but that doesn't make our failed attempts for a 2nd any less discouraging.

It's comforting to know so many are going through the same emotional (and economic) roller coaster.
TTC since 2005
Me: age 38, unexplained female infertility
DH: age 39, no probs
IUI #1- Jun '09 BFN
IUI #2- Aug '09 BFN
IVF #1- Nov '09, 12 eggs, 8 fertilized, 2 tx day 3, 0 frozen :bfp: Daughter, Bronwynne, born Aug 2010
IVF #2- Jul '13, 13 eggs, 7 fertilized, 2 tx day 3, 0 frozen, BFN
IVF #3- Apr '15, 12 eggs, 7 fertilized, 2 tx day 5, 0 frozen, BFN
IVF #4- Jul '15, 15 eggs, 15 fertilized, day 5/6 biospy, 4 snow babies, PGD: 2 normal, 2 abnormal- disgarded
FET #1- Sep 8th, transferred 2, :bfp: Beta #1--995, #2--3773! u/s-- 2 Oct, singleton, Herman2!
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Re: 3 or more failed ivf stim cycles

Postby Rebcat » Wed Mar 25, 2015 2:48 am

Hi Adventurer, thank you for your reply. I can't recall my levels off the top of my head and the assay they use for AMH here has different units so we can't compare directly. But basically I have somewhat diminished ovarian reserve but not really low. My AMH is moderately low for my age, but I always return other hormone levels within normal ranges. I just dont ever seem to respond well to stimulation. DH has low sperm count but we have done icsi to account for that. I have unexplained infertility, no known issues. We are going to use donor sperm for the next cycle. I am also going to try acupuncture for the first time. That is reassuring that you think it helps. I can't believe how many follicles you get in your cycles!

Hi Herman, welcome :) I am so glad that this forum has given girls like us the courage to be part of these discussions again. You are so right about the emotional.... and economical roller coaster. My clinic does three day transfers and genetic testing is just not an option financially, so I am in the same situation as you. I have only ever been able to freeze one embryo and that was the closest I came to success. Do you know what protocol you will be doing?

Hi to everyone else and I hope all is going well.
Me 37, DH 39 , TTC#1 since 2009 :(
IVF #1 Oct 2010 - BFN
FET Feb 2011 - BFP, low hcg, m/c
IVF #2 Nov 2011 - BFN
IVF #3 Apr 2012 - BFN
IVF #4 2013 -BFN
IVF #5 2014 -BFN
Donor IUI x 4 2014 - BFN x 4
IVF #6, July 2015 - shocking BFP!
HCG day 14 - 150
HCG day 17 - 800
Waiting for 7 week scan
It's twins... can't believe it.
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Re: 3 or more failed ivf stim cycles

Postby Hope2015 » Wed Mar 25, 2015 6:09 am

Hey there

Ive been well, and feeling much better. For 2 days some sharp quick pain in my side (for a second). I think my ovaries are trying to adjust from last cycle.

Im good on the outside, feeling better physically, but im holding to some anger. Im cringing inside when I hear talk of babies or someone having 'another' baby.
Im protecting myself feeling very free and proud of our lives, my achievements, future endeavours.
So last month planning to have this huge change, of perhaps being pregnant and now.... nothing.

Still a little bloated.

Rebcat you are a brave and strong lady.
Enduring the stims. This will make us stronger. I know youve been through a lot but I think time is on your side.

Roar were you diagnosed with endo. only through a lap? As ive thought about a lap. to check inside. Hope u dont mind me asking.

Asking for a Miracle for ladies who have waited.
Its not too much to ask
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Thu Mar 26, 2015 6:31 am

Hi all,,,

Rebcat- I am not 100% with lingo but here is my plan. I actually respond very well to stims and produce eggs which in turn produce embryos (fresh cycle 1 - 1 fresh embryo transfer & 6 frozen, fresh cycle 2 - 1 fresh transfer &4 frozen). My issues is when I get pregnant I can't hold the pregnancy. So my first cycle and this one will be the same ,,
day21 start lucrin to suppress
Day 1 gonal-F 125iu daily with folate, aspirin and ovidrel shots (one click) every second day (apparently helps with egg quality?).
Approx day 14 ultrasound etc and trigger with ovidrel
From embryo transfer aspirin, folate , clexane, prednisoline (steroid) daily.
I just had my day 2 bloods done and was really that my FSH was 11.1. Not super fantastic but I just prayed for under 12 as last FET it was 12.4 and was expecting something higher.

Herman 2 - hello!! I feel we have had very similar histories. I too fell pregnant in 2009 after my first lap and had a little boy in 2010. However no pregnacy is sticking since. Over here Iin Australia we are very lucky as one fresh cycle costs approx $8000 (where I am) but do get some back. Thus out of pocket $3800 by the end of it. Nothing like elsewhere around the world. Infact our first cycle was $1800 out of pocket so in 3 yrs it's gone up $2K. Exciting to have your retrieval soon, we always do 3 day transfers and have had 50% success rate so far. I agree, we are so grateful for our little boy but there is still a piece missing from our hearts.

Hope- it's so difficult to be in the position we are in and be around or hear about babies. how's the bloat going?? I always hyper stimulate it's just awful!! I was diagnosed via a lap, my first one, but I think I always knew I had it for young. My periods were horrendous from very young. It was actually nice to be diagnosed and not just think I was a big sook that couldn't Handle a bit of pain. Turns out that my pain isn't quite comparable to a non endo person. If you do do a lap make sure your surgeon is specialised in endo. It's a very easy thing to miss to an untrained eye, unless of course you have extreme damage done. I wish and pray for your miracle to be now.

as for me I have had the heaviest period OF MY LIFE,, I can't even explain it. The bonus is it's been pain free but thank my surgeon for that as my last lap in jan helped a lot,, so all levels were good and still in my month off being tracked to ovulation and 7dpo for lucrin start.

Hope everyone is feeling positive
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
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Re: 3 or more failed ivf stim cycles

Postby Herman2 » Fri Mar 27, 2015 5:47 am

Thanks to everyone for replying. I've read many threads over the years bit this is the first I've joined.

I'm doing an antagonist protocol, but folies are slow this time around...what a difference 2 yrs @my age makes! started with Gonal aND menapur, no aspirin this time, 75iu, doubled after 2 days and up again to 225iu. I only had 6 eggs, which even for me is low...although as my friends say, 'it only takes one!' I'm also working again with same clinic that gave us our daughter. They have a 100% shared risk program. $20K (U.S.) for up to 6 fresh cycles then if i don't take home a baby, 100% money back. BUT meds are not included and if we are successfull on the 1st, we've basically paid over double for the cycle....shared risk. Does give us a better piece of mind this time around.

Roar- congrats on your son. positive thoughts for another success. My daughter is 4 1/2 now and just amazes be every day, but I knew the moment she was born that I wanted her to have a sibling. I came for a large family (5) of us, plus I have an identical twin and she has been struggling with infertility too.

Hope- keep positive, good to know you are feeling better

Adventurer- 33 eggs?! Holy Sh*t! You're an inspiration.

Rebcat- I've been doing acupuncture for the last 6 months...it's been good for the stress, but I'm not sure it'll make a huge difference for me. As my acupuncturist says though, 'you don't have to believe it, for it to work!' I did fertility yoga and a fertility diet as well for the last year...the things we do.

Anyhow, I'll keep you all posted as the days unfold. Hope you all have a great weekend.

BTW- Herman...combo of her and man, we kept the gender of our daughter a surprise until she was born. I did a natural home birth....a whole other story....and I needed all the motivation I could get. There are very few surprises in life and that was one of them. Cheers, everyone!
TTC since 2005
Me: age 38, unexplained female infertility
DH: age 39, no probs
IUI #1- Jun '09 BFN
IUI #2- Aug '09 BFN
IVF #1- Nov '09, 12 eggs, 8 fertilized, 2 tx day 3, 0 frozen :bfp: Daughter, Bronwynne, born Aug 2010
IVF #2- Jul '13, 13 eggs, 7 fertilized, 2 tx day 3, 0 frozen, BFN
IVF #3- Apr '15, 12 eggs, 7 fertilized, 2 tx day 5, 0 frozen, BFN
IVF #4- Jul '15, 15 eggs, 15 fertilized, day 5/6 biospy, 4 snow babies, PGD: 2 normal, 2 abnormal- disgarded
FET #1- Sep 8th, transferred 2, :bfp: Beta #1--995, #2--3773! u/s-- 2 Oct, singleton, Herman2!
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Re: 3 or more failed ivf stim cycles

Postby Rebcat » Tue Mar 31, 2015 10:05 pm

Hello girls.

Herman, love the name! I had to admit that I was wondering... If I ever get the chance, I think I would want to keep gender a surprise also. I haven't started the acupuncture yet, but I have been in contact with the provider. She said she wants to do some sessions when I start my meds and then when the embryo (fingers crossed) is implanted. I don't usually go for things without a strong medical evidence base, but as long as it does no harm, then it can't hurt to try.

Roar, thanks for sharing your cycle. I am interested in the combinations of meds you are taking. In the past I have just had the basic down regulation then stimulation with progesterone for luteal support. I don't know if my clinic would entertain the idea of trying other stuff but I will raise it with them. They are currently liaising with other colleagues to figure out the best cycle for me. I am particularly interested in the ovidrel for egg quality.

Well I hope that everyone is well, would love to hear some updates.
Me 37, DH 39 , TTC#1 since 2009 :(
IVF #1 Oct 2010 - BFN
FET Feb 2011 - BFP, low hcg, m/c
IVF #2 Nov 2011 - BFN
IVF #3 Apr 2012 - BFN
IVF #4 2013 -BFN
IVF #5 2014 -BFN
Donor IUI x 4 2014 - BFN x 4
IVF #6, July 2015 - shocking BFP!
HCG day 14 - 150
HCG day 17 - 800
Waiting for 7 week scan
It's twins... can't believe it.
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Re: 3 or more failed ivf stim cycles

Postby Herman2 » Wed Apr 01, 2015 8:30 am

Looks like I may be triggered today for a Good Friday retrieval. Follies are doing better; Doc says 4-7 ideally sized eggs with another 3-4 smaller ones, so he is pleased despite my slow start. We are still looking at the genetic 5-day testing and a later FET, but if they are not looking good, then a 3 day transfer--which would match out last 2 IVFs.

I don't know about you but easter weekend for egg retrievals seems like a good omen! I'll let you all know.
TTC since 2005
Me: age 38, unexplained female infertility
DH: age 39, no probs
IUI #1- Jun '09 BFN
IUI #2- Aug '09 BFN
IVF #1- Nov '09, 12 eggs, 8 fertilized, 2 tx day 3, 0 frozen :bfp: Daughter, Bronwynne, born Aug 2010
IVF #2- Jul '13, 13 eggs, 7 fertilized, 2 tx day 3, 0 frozen, BFN
IVF #3- Apr '15, 12 eggs, 7 fertilized, 2 tx day 5, 0 frozen, BFN
IVF #4- Jul '15, 15 eggs, 15 fertilized, day 5/6 biospy, 4 snow babies, PGD: 2 normal, 2 abnormal- disgarded
FET #1- Sep 8th, transferred 2, :bfp: Beta #1--995, #2--3773! u/s-- 2 Oct, singleton, Herman2!
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Re: 3 or more failed ivf stim cycles

Postby Adventurer » Wed Apr 01, 2015 3:45 pm

Good luck Herman! Your plan for genetic testing vs. 3 day transfer is very reasonable. You can always switch to a 5 day FET depending on day 3 results.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Thu Apr 02, 2015 7:15 am

Hello All!

Herman- love the name too. We didn't find out the gender of our pregnancy either. And if we are ever lucky enough to have another successful one I don't think we would again. Loved the surprise!! The shared risk program sounds good, indie read somewhere that if you don't have a pregnancy after 3 cycles then chances are slim to have a baby,,, I chose to ignore such a stat!! We are all different so the 6 cycles on offer sounds great! Excellent news with ur follies. Best of luck for your retrieval let us know how you went!

Rebcat- it's always interesting to see what other clinics do. Mines open to lots of different ideas but my speickaist has led most of the ideas in our talks. Which is good as that's what I need,, expertise!!

Annisa- not sure you are still checking in but u mentioned an Easter transfer, hope it's all gone well and or goes well. Easter is all about new life let's hope it's a start for us all!

Me- tracking my cycle still @ clinic to identify cycle day 21 for lucrin start. Usually I ovulate on day 18,, needless to say in ovulating day 11/12,, WTF,, seriously so we are giving the natural way one last try before going through all the fresh stuff again,,, I have never wanted something so much right now to work. What I would give to fall naturally and not have to go through a fresh cycle. The thought of OHSS again makes me fell ill!!

Hope everyone else is well!
Happy Easter
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
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Re: 3 or more failed ivf stim cycles

Postby Herman2 » Fri Apr 03, 2015 4:13 pm

Just a quick update. I was triggered last night, 2am actually and a very amazing neighbor who happens to be a nurse did the honors. My DH can't stand needles and about fainted when I told him the 2am time meant he was probably doing it.

Retrieval is tomorrow at 2pm EST. Wish us luck!
-- Herman
TTC since 2005
Me: age 38, unexplained female infertility
DH: age 39, no probs
IUI #1- Jun '09 BFN
IUI #2- Aug '09 BFN
IVF #1- Nov '09, 12 eggs, 8 fertilized, 2 tx day 3, 0 frozen :bfp: Daughter, Bronwynne, born Aug 2010
IVF #2- Jul '13, 13 eggs, 7 fertilized, 2 tx day 3, 0 frozen, BFN
IVF #3- Apr '15, 12 eggs, 7 fertilized, 2 tx day 5, 0 frozen, BFN
IVF #4- Jul '15, 15 eggs, 15 fertilized, day 5/6 biospy, 4 snow babies, PGD: 2 normal, 2 abnormal- disgarded
FET #1- Sep 8th, transferred 2, :bfp: Beta #1--995, #2--3773! u/s-- 2 Oct, singleton, Herman2!
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Re: 3 or more failed ivf stim cycles

Postby Roar79 » Sat Apr 04, 2015 1:16 am

Good luck!!! Will be thinking of you. Exciting and scary times,,, but positive thoughts to you xxxx
2009- diagnosed endo via lap
2010- live birth no meds
2012- lap 2- preg 2 - loss #1 @7wks
2013- IVF 1- preg3 - loss #2 @7wks
FET- preg 4 - loss #3 @8wks
Diag w MTHFR & septum (corrected via surgery)
FET- neg
2014 - IVF 2 - neg
FET - neg
FET - preg 5 - loss #4 @10wks
Meds- Aspirin, Vit Bs etc, MTHFR folate, clexane, prednisolone
Lap #5 - septum recorrected, more endo removed
On estrogen for 4 weeks & HSG SCHEUDLED to view septum 'healing'
Feb- checked septum. Hasn't healed. 3rd and final surgery correction.
Ivf #3 - April/May- our last try
Natural preg #6 whilst on down reg lucrin for cycle #3
Heartbeat @7wks 143bpm, 8wks, 9wks, 10 wks YAY!
12 wk scan -TICK! Told family
19 wk anatomy scan - TICK!
Due December 29th 2015
Born 18th December 2015- girl - Georgia
I'm DONE
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Re: 3 or more failed ivf stim cycles

Postby Herman2 » Sat Apr 04, 2015 11:45 am

Hi ladies. Just finished with the Easter retrieval. 14 eggs! We are so pleased. Will get a fertilization report tomorrow. Happy Easter to you all.
TTC since 2005
Me: age 38, unexplained female infertility
DH: age 39, no probs
IUI #1- Jun '09 BFN
IUI #2- Aug '09 BFN
IVF #1- Nov '09, 12 eggs, 8 fertilized, 2 tx day 3, 0 frozen :bfp: Daughter, Bronwynne, born Aug 2010
IVF #2- Jul '13, 13 eggs, 7 fertilized, 2 tx day 3, 0 frozen, BFN
IVF #3- Apr '15, 12 eggs, 7 fertilized, 2 tx day 5, 0 frozen, BFN
IVF #4- Jul '15, 15 eggs, 15 fertilized, day 5/6 biospy, 4 snow babies, PGD: 2 normal, 2 abnormal- disgarded
FET #1- Sep 8th, transferred 2, :bfp: Beta #1--995, #2--3773! u/s-- 2 Oct, singleton, Herman2!
Herman2
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Re: 3 or more failed ivf stim cycles

Postby Rebcat » Sat Apr 04, 2015 7:56 pm

Good luck Herman, fingers crossed. It has to be a good omen that it is an easter egg retrieval!!!
Me 37, DH 39 , TTC#1 since 2009 :(
IVF #1 Oct 2010 - BFN
FET Feb 2011 - BFP, low hcg, m/c
IVF #2 Nov 2011 - BFN
IVF #3 Apr 2012 - BFN
IVF #4 2013 -BFN
IVF #5 2014 -BFN
Donor IUI x 4 2014 - BFN x 4
IVF #6, July 2015 - shocking BFP!
HCG day 14 - 150
HCG day 17 - 800
Waiting for 7 week scan
It's twins... can't believe it.
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