Diminished ovarian reserve

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Diminished ovarian reserve

Postby spp5106 » Thu Oct 22, 2015 9:35 am

As part of our pre-IVF testing, I just found out I have diminished ovarian reserve. I'm 33 and feeling devastated by the diagnosis. I am about to start three weeks of BCP with an ER hopefully sometime around Thanksgiving.

My RE said he is going to adjust the meds I get accordingly. I've started taking DHEA and CoQ10 now. Anyone out there with IVF experience or an IVF success story after a diminished ovarian reserve diagnosis? Is there anything else you did that you think helped?

Thanks so much in advance -- I could really use some hope right now.
Me and DH: both 33. No known cause of infertility.
TTC since Sept 2014.
BFP in Nov 2014 but ended in MC at 7.5 weeks.
IUI #1 Sept 2015: BFN.
IUI #2 Oct 2015.
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Re: Diminished ovarian reserve

Postby faithkeepsmegoing » Fri Oct 23, 2015 8:37 am

@spp I’m so sorry to hear you got such bad news. I got the same news early this year. I don’t have a success story yet but I can definitely relate. What was ur AMH level? Mine was .76 which is pretty low for someone at the age of 33. On a good note, I did get pregnant with my 3rd IUI in May but I had a MC at 8wks (I guess it just wasn’t our time yet). I had my 1st IVF in Sept which turned out to be a BFN, it sucked but it gave me a better perspective as to where I’m at with things. Most docs tend to use the usual Long lupron protocol which is when they have u get on bc pills for 3 weeks and Lupron the last week of ur bc pills, for most DOR patients it tends to oversurpress them which in turn means slow progress and less follicles at retrieval. It’s a pretty standard protocol which does work for most patients but is a slim chance for us slow responders. I was happy to hear my RE changed my protocol this 2nd round to the antagonist protocol which is no suppression at all, we went straight to stimming. I have my day 5 US tomorrow so, I’ll let you know if things look any diff than last time. Remember, you’re not gonna have the same stats as everyone else. In our cases, we will always produce less follicles at stimulation but as long as the quality is good which is what they count on due to our age then we’re still in the race. Unfortunately the 1st ivf is always a practice run, they don’t really know what’s gonna work or how our bodies will respond. I wish u all the luck in the world on this journey. Let me know if you have any other questions. Here’s to getting our bfp’s soon….
TTC 17 months
Me - 33 (low ovarian reserve)
DH - 32 (perfectly fine)
Unexplained infertility
IUI #1 & #2 - BFN's
IUI #3 - 04/28 BFP!
MC - 06/09 :(
1st IVF 09/2015- BFN
2nd IVF 10/29 - BFP!!!
Beta 349 18dpo
12/01 6.5wk ultrasound - saw heartbeat flickering & growing on point
12/11 2nd ultrasound 8wks 1day? Heartbeat 158
01/05 1st trimester screening - Harmony Test (12wks 1 day) Perfect ultrasound, heartbeat 171.
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Re: Diminished ovarian reserve

Postby Adventurer » Fri Oct 23, 2015 10:27 am

Sorry to hear you have DOR. :( However, because you are young, I think you have an excellent chance to have a baby on the right protocol. I recommend you check out Dr. Sher's blog www.haveababy.com and read about the agonist-antagonist conversion protocol if your cycle doesn't work out. It's a very good protocol for DOR (I'm proof of that). If you need the details of this protocol, I can PM you. If BCPs and Lupron are used correctly in terms of dose and timing, the ovaries should NOT be suppressed. Using Dr. Sher's protocol (starting with BCP and Lupron), I had 8 antral follicles (4 on each side) at baseline but ended up with 33 eggs on 300 Gonal F/37.5 Menopur and Cetrotide as antagonist. The idea of the agonist antagonist is to start with the agonist (Lupron) and then convert to the antagonist (Cetrotide), hence the protocol name.

In terms of supplements, I took a battery of vitamins including DHEA but when it came time for my cycle with Dr. Sher, I discontinued the DHEA. See my siggy for the additional supplements I took. The best form of CoQ10 to take is Ubiquinol which is more expensive but better absorbed by the body. The dose is 600 mg per day.

The other adjunct that helped me a lot is fertility acupuncture to improve ovary and uterine function as well as circulation to the pelvic organs. Acupuncture can be used 1 hour before transfer and 1 hour later to assist with implantation as well.

Good luck!
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: Diminished ovarian reserve

Postby Bg99 » Fri Oct 23, 2015 10:00 pm

Hi! I too have low egg reserve. I'm 34 and my AMH was like .7. Looks like I only have 6 follicles and I should trigger shot on Monday, with hopes of retrieval Wed. I'm trying not to think of the numbers, and just hope the quality is good. In a way it's good, as DH and I didn't want to be faced with what to do with extra, unused embryos down the road. That being said, I hope for at least one or two good embies.
Me - 34 Low ovarian reserve
DH - 34 Low count (4 million) low motility
1 bio-11 yo,conceived naturally
1 adopted DS-6 yo
TTC since 2005

IVF with ICSI

10/27/15 - 6 good follicles so far
ER 10/29
7 eggs retrieved!
6 eggs fertilized
3 embryos made it to day 5 blasts
ET-11/3/15 transferred two embies, 1 perfect, 1 fair
3rd embie didn't make it to freeze :(
**In the 2WW!!**
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Re: Diminished ovarian reserve

Postby nicoleT419 » Sat Oct 24, 2015 7:00 pm

I am 33 also and have DOR. My AMH was about 0.9. My first IVF cycle was a BFN, I did birth control first, no lupron and then I was on menopur and gonal F. We added ganirelix in the middle of that. Anyways, I ended up with 8 eggs, 6 fertilized, we transfered 2 and it was a BFN. The rest of the embryos never made it to freeze. I am starting over this cycle with what is called the estrace priming protocol. I am going to start the estrace after I ovualte, then will start stimulation in nov when I get my period. I agree with faith that you should not compare yourself to others during stimulation because you won't have as many follicles. But quality is the most important and just because you have low reserve doesn't mean that the quality of your eggs is poor. Especially being at a young age this is more true. I will prob have an ER around Thanksgiving as well, if you want to join me and faith on the "IVF 2.0 starting mid October" thread. Good luck :)
Me: 33 DH: 36
TTC: since 2013
May 2015: HSG revealed left hydrosalphinx and right tube probably blocked, DH 2% morph- IVF only way to get preg
June 2015: left salpingectomy
low ovarian reserve
IVF #1 sept 2015- negative :(
IVF#2 dec 2015- 12 eggs retrieved, 6 fertilized, 3 good embryos transfered at day 3
12/21- ???????
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Re: Diminished ovarian reserve

Postby T2015 » Sun Oct 25, 2015 9:00 am

I too had the ed speech twice i guess were my best chances at 70-80% but with my own eggs only 20% of conceiving. I have a low amh of 0.43 and high fsh of 18.3. I am taming royal jelly wheat grass dhea coq10 prenatal and baby aspirin. Its so hard to accept a de sp i am teying herbs and supplwments and will have a injectibles with gonel f and iui and trigger shot i believe next month so i am really hoping that one is a success if not i will go ahead and try on my own for 6 months herbs and supplements with ipk and see what happens before i go into ivf route anyone have suggestions to my issues should u try the 20% ivf with my own wggs i just dont wanna waste money i dont have it hard for me to get financial help due to my credit any suggestions i would love to hear
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Re: Diminished ovarian reserve

Postby Adventurer » Sun Oct 25, 2015 5:13 pm

T2015: How old are you? That very much would change your chances using your own eggs. If you are over about age 35 with those stats, then you most likely need IVF to increase your chances to conceive. With an FSH of 18.3 and an AMH of 0.43 means that you should probably try a series of IUI with injectables if IVF is not a financial option. Of course, you just never know and many people become pregnant on their own in your situation.
Me - 41
DF - 35
AMH 23.8 pmol/L
Supplements: Ubiquinol 600 mg, Folate, vit D3, vit C, vit E, vit B6, Omega-3, royal jelly, L-Arginine, Chinese herbs
Acupuncture: 2x/week
IUI #1 (1/14): Femara 12.5 mg CD3-7, 3 follies, BFN
IVF #1 (2/14): 7 eggs - 5 fertilized with ICSI - 4 blasts biopsied for PGS/4 snowbabies - 1 abnormal, 3 no result
IVF #2: (4/14) 19 eggs - 13 fertilized with ICSI, 5 blasts/snowbabies
IVF #3: (6/14) 16 eggs - 10 fertilized with ICSI, 4 blasts/snowbabies
IVF #4: (8/14) 33 eggs - 27 mature - 22 fertilized with ICSI, 2 day 5 blasts transferred - BFN, 10 snowbabies, 4 remaining PGS normals
FET #1: (11/14) single embryo transfer - :bfp: at 5dp5dt
Beta #1 at 8dp5dt 134
Beta #2 at 10dp5dt 383
Beta #3 at 12dp5dt 955
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Re: Diminished ovarian reserve

Postby Emme1982 » Mon Oct 26, 2015 4:35 am

Hi ladies! Me too- DOR, age 33...FSH somewhere near 20, AMH almost non existent (if I remember correctly).
Still working on it- but still not convinced that the DOR diagnosis is (at least for me) as they present it- a donor-egg only street...
Good luck everyone, hang in there.
TTC since: December 2011
--------------------------------
July 2014: Diagnosed with poor ovarian reserve
September 2014: Clomid round 1
October 2014: Clomid round 2
December 2014- January 2015: IVF round 1- negative
March 2015- spontaneous (unmedicated, babydance only) chemical pregnancy.
We saw a doctor during the summer in Europe, he suggested endometriosis may be an issue.
New doctor- waiting for AF to do first test (3rd day of period).
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Re: Diminished ovarian reserve

Postby spp5106 » Wed Oct 28, 2015 8:33 pm

Thank you so much everyone for all the advice and support. This community is amazing!

My ER is tentatively scheduled for early December. Nicole, I will definitely join you on the other thread. And best of luck to everyone!
Me and DH: both 33. No known cause of infertility.
TTC since Sept 2014.
BFP in Nov 2014 but ended in MC at 7.5 weeks.
IUI #1 Sept 2015: BFN.
IUI #2 Oct 2015.
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Re: Diminished ovarian reserve

Postby Emilia80 » Thu Nov 05, 2015 4:38 pm

Just wanted to let u ladies know that my amh was 0.95 too I'm 35 and have one blocked tube and fsh was 8! I was told I would need Ivf. I got pregnant naturally on my first try ( once partner stopped taking testosterone which was the cause of me not getting pregnant earlier, once he stopped that bang I got pregnant)! First go! So amh is not a reliable number. I would have AFC checked which is a better indicator, my AFC was 16, so as u can see didn't match up to my low amh.
Pls don't let the numbers discourage u. Remember quality over quantity .
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Re: Diminished ovarian reserve

Postby Emilia80 » Thu Nov 05, 2015 4:41 pm

Also. Check your vitamin d levels, this lowers ur amh. Vitamin d plays a huge role in fertility. If ur taking cq10 make sure it's the ubiquinol brand and not the other type, otherwise just wasting money, also take essential fatty acids vitamins and magneusim.
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Re: Diminished ovarian reserve

Postby T2015 » Sun Apr 17, 2016 12:11 pm

Adventurer: i am 30 i found a new re i am now seeing i was going to start a few iui imjectibles cyclw but had a cyst waiting on my bw results and will see her tomm for another us i took a break mentally and emotionally it was hard but now i found the right re that says we dont care about quantity we are going for quality
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