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IVF/PGD-help devastated and confused

Sat Sep 16, 2017 2:00 am

Hi
I've just finished my first round of IVF with PGD and got a BFN with my third and final frozen embryo. I'm devastated and can't think why it's not working everything is normal we have no fertility issues everything in the tests came back bang on average for both of us even had a further test on my womb cavity which they say is normal we have no health issues and are having PGD as a carry a genetic condition that only effects men. The doctors refused to transfer 2 embryos because of my age (31) so I'm at a loose end weather to go for round 2 or try naturally. I did not think I'd cope well if the tests came back positive for the condition of we got pregnant naturally which is why I went for the PGD but it's not been easy and it looks like it's not working for us and we really want a child so naturally it may have to be. I've a 75% chance of a healthy baby so I guess the odds are good.
I would just like advice is it worth a second round if this one has failed is a second likely to? Anyone been in this situation before?
I get 3 rounds on nhs but have to go back and forth to London for my treatment and everything takes a while I'm worrying I'm getting no younger (I'm 32 in Feb) and I know the older I get the chance of me conceiving naturally gets less and less this round from egg collection to transfers has taken 9 months by the time I start round 2 we will be a year if not more in hopefully someone who has been in this postition can help
Thank you xx

Re: IVF/PGD-help devastated and confused

Sun Sep 17, 2017 2:23 am

I honestly don't know what to say...is a tough decision.
I guess all you can do is you and your partner talk about everything and make a decision together.
Good luck!

Re: IVF/PGD-help devastated and confused

Fri Oct 27, 2017 4:00 am

Best of luck with any decision of yours xx

Re: IVF/PGD-help devastated and confused

Thu Apr 19, 2018 2:38 am

Hi, Muffin! I vote for doing the same thing, though the decision is too personal.
PGD tests not only for genetic diseases but for chromosomal abnormalties. At the age 31+ closer to 50% of our embies are going to be chromosomally abnormal. Most of these abnormalties are fatal and end in mc. Some, like trisomy21 may result in a viable birth. To exclude all these negatives I'd go for PGD testing whilst cycling#2 as well.
Wish you all the best of luck whatever your decision is.

Re: IVF/PGD-help devastated and confused

Sun Jun 10, 2018 6:45 am

We had my first child naturally after an ectopic pregnancy where one tube was left severely damaged. Had huge troubles falling pregnant with baby number 2. No clear explanations why we couldn't fall, it was so frustrating! Finally after 11 transfers (4 rounds I think) I got my baby Cam!! I had him at age 37. I feel so lucky! Best of luck

Re: IVF/PGD-help devastated and confused

Fri Jun 15, 2018 3:05 am

Muffin1986 wrote:Hi
I've just finished my first round of IVF with PGD and got a BFN with my third and final frozen embryo. I'm devastated and can't think why it's not working everything is normal we have no fertility issues everything in the tests came back bang on average for both of us even had a further test on my womb cavity which they say is normal we have no health issues and are having PGD as a carry a genetic condition that only effects men. The doctors refused to transfer 2 embryos because of my age (31) so I'm at a loose end weather to go for round 2 or try naturally. I did not think I'd cope well if the tests came back positive for the condition of we got pregnant naturally which is why I went for the PGD but it's not been easy and it looks like it's not working for us and we really want a child so naturally it may have to be. I've a 75% chance of a healthy baby so I guess the odds are good.
I would just like advice is it worth a second round if this one has failed is a second likely to? Anyone been in this situation before?
I get 3 rounds on nhs but have to go back and forth to London for my treatment and everything takes a while I'm worrying I'm getting no younger (I'm 32 in Feb) and I know the older I get the chance of me conceiving naturally gets less and less this round from egg collection to transfers has taken 9 months by the time I start round 2 we will be a year if not more in hopefully someone who has been in this postition can help
Thank you xx

The pain that you've been feeling can't be compared to the joy that's coming. :hugs: I truly think you're on the right track with PGD testing. PGD is not only for genetic diseases. It's also for chromosomal abnormalties. Being closer to ripe age will more likely seem 50% or more of our embryos are going to be chromosomally abnormal. Most of these abnormalties are fatal and end in mc. Some like trisomy 21 (Down's syndrome) may result in a viable birth. So it's useful you get your embies tested for all those things. Besides you're given 75% chance of having a healthy baby which is superb and can be definitely counted on. Yet one more thing. If you failed with shot#1 it doesn't actually mean you'll fail with #2!! You're still capable of catching that very super healthy egg!! (Me-40yrs oldie. dx: endo & pcos. Had 2 lapos with no actual result. My last one caused my left ovary removal. We tried 2 fresh ivf cycles with oe which failed. Switched to donor egg. Got prego with shot#1 de ivf.) Keeping you in my prayers!

Re: IVF/PGD-help devastated and confused

Fri Feb 15, 2019 11:34 am

It's really hard to pinpoint the reasons for failure. IVF is a confusing problem, to be fair! It can work out in the first attempt. It can work for you in the fifth! I just hope you experience a bit of change in luck. Sending you lots of baby dust! Hope you get that BFP!

Re: IVF/PGD-help devastated and confused

Wed May 15, 2019 4:04 am

It is important to remember that PGD is not 100% accurate!! This is because only one cell is tested. The technique is quite challenging. It requires great expertise. So one has to be sure the lab is doing the best. As for the PGD costs. The testing ranges from approximately $2k to $5k and is not covered by most insurance companies. (The clinic we'd been with has PGD included into the package price. Which was quite a rare thing to see at time we were doing research) Then one should know that not all IVF centers do PGD! The experimental techniques require great expertise and should only be done by qualified personnel. It is preferable if the lab performing PGD has a specially trained medical geneticist responsible for the PGD laboratory. So if one is considering doing PGD, one should make certain the laboratory is experienced. Also that the lab does a large number of cases and is certified. It might be useful to ask your doctor at the IVF clinic or the lab director the following questions: What training has the PGD laboratory personnel who are performing the testing have? How long have they been doing the procedure? When will you get the results of the PGD? What will happen if all the embryos are genetically abnormal? What the clinic’s success rate is for frozen embryo transfer following embryo biopsy? etc.

Re: IVF/PGD-help devastated and confused

Tue May 21, 2019 5:27 pm

I am really sorry to read this. I hope things get better for you. I can understand how hard this must be for you. I would suggest going forward with the second cycle. However, this time make sure that the doctor you visit is experienced and knows how things are carried. This will definitely have a positive impact on your process. Good luck to you. Sending baby dust your way.
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