Does sperm age matter in IVF?

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Does the age of sperm matter in IVF?

Yes - it plays a big roll in nfertilization and embryo quality
6
60%
No - only the age of eggs matters
3
30%
Not sure
1
10%
 
Total votes : 10

Does sperm age matter in IVF?

Postby deneice2004 » Thu Jan 22, 2009 11:41 am

Just curious what everyone has been told regarding the age of sperm and fertilization.

My clinic says that "older" sperm (meaning the mans age) do not fertilize eggs as well as "younger" sperm. A lot of people are still under the assumption that sperm age is not a factor in fertilization and the quality of embryos. Fertilization rates are lower and more embryos arrest due to chromosonal abnormalities.

I have seen many egg donors who produced high quality eggs been made to feel like it was their fault the fertilization rates were low when an old IFs (Intended Father) sperm was used.

Example: I just had 18 eggs retrieved. All 18 were mature. I gave half to a friend. So I have 9 and she has 9. 8 out of 9 of mine fertilized with DHs sperm (he is 30). My IM only has 4 out of 9 fertilized by her DH (in his 50s). I have many more examples also I could also post.

I just wonder why people would spend so much money to use "old" sperm. They would not use old eggs.....is it just that so many are uneducated in this department or you just want at least one parent genetically tied to the child? My RE makes it clear pregnancy rates with sperm from 50 yr old men and above is lower than average.
Last edited by deneice2004 on Thu Jan 22, 2009 2:37 pm, edited 1 time in total.
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Me 28, DH 31
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TTC #1 since 08/2007
5 IUIs
1 IVF
02/2009 Miscarriage
04/2009 Miscarriage
06/2010 Miscarriage
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Postby deneice2004 » Thu Jan 22, 2009 12:07 pm

Here are the main issues with older sperm:

Decreased Motility: Sperm that has not matured will not have the adequate motility to reach and penetrate the egg. In addition, with age comes a decreased ability to have strong ejaculations, thus, decreasing the distance that the sperm will travel upon ejaculation.

Decreased Strength: Immature sperm will not have the needed strength to travel the distance to the egg, nor the needed strength to penetrate the membrane for fertilization.

Decreased Potency: The force of the ejaculatory squirt in young men is often powerful and can eject the sperm some distance. The force of the squirt, propelled by the powerful contraction of the bulbocavernosus muscles, is much less in older men than in younger men. Thus, in every measurable way male potency is clearly affected by age.

Altered Genetic Make-Up: As men age, sperm cells can accumulate mutations that are passed to offspring. Regardless of age, sperm continues to reproduce through division. If a sperm becomes altered or mutates, any other sperm that is produced by the natural division will also be altered or mutated. Each successive division introduces a slight risk of error in the genetic material of the new sperm, which is passed on to the children

And an interesting article:

Male Fertility, Age and IVF Success
In yet another study, this one also conducted in Israel at the Assuta Medical Center in Rishon LeZion, researchers found a link between male age and IVF success rates, even when donor eggs were being used.

For women over age 40 or women with low-ovarian egg reserves, donor eggs often offer the best chance for IVF success. What if the man is also older, though? Does age make a difference?

According to this research study, age did have an effect on the outcome. The study compared the sperm and embryos of couples whose IVF treatment led to pregnancy with couples for whom IVF treatment failed. All the couples in this study were using egg donors, so the age of the mother was not an issue.

They found that until age 40, the man’s age didn’t seem to have a significant effect. After age 40, though, the quality of the semen diminished, possibly leading to IVF treatment failure. They also found that embryos in the nonpregnant group were of lower quality than the pregnant group, perhaps related to poorer quality sperm.

The Final Answer:
We already know that as a woman ages, her fertility decreases, but as these studies show, age also has an effect on male fertility. Both men and women must contend with their biological clocks.
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Me 28, DH 31
Married 09/2003
TTC #1 since 08/2007
5 IUIs
1 IVF
02/2009 Miscarriage
04/2009 Miscarriage
06/2010 Miscarriage
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Postby jlg » Thu Jan 22, 2009 12:09 pm

My DH is 48 and our RE told us from the start that there was an increased chance of chromasomal abnormalities. That may very well be the reason for our early m/c. I had 7 mature eggs, 6 fertilized, but only 3 made it to transfer...we transferred all 3. We have considered donor sperm as a last result, but we really want to have a child that is biologically both of ours. I think the biggest difference is that women have all the eggs we will ever have when we are born. When they find through testing that you have low ovarian reserve or poor quality eggs...that's that. With men, they are constantly producing more sperm and one "batch" may be healthier than another. Some men have fathered healthy children well into their 60's and 70's...look at Hugh Hefner, Warren Beatty, and Tony Randall!!! I think the father's age is definitly a factor, just not as big a factor as the mother's.
*Me: Jennifer-34 *DH: Tom-50
*DD: Krista-born 6/9/10
*Three DSD's-26, 24, and 18
*TTC 3.5 years with severe MFI post VR
*Four IUI's, three IVF/ICSI's, and one miscarriage later...we finally have our miracle!

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Postby mereyurk » Thu Jan 22, 2009 12:40 pm

I agree with you girls. They do say the healthier ones will decrease with age but of course can father children in their 60's. I'm sure women could to if they didnt go through menapause and still had eggs left but less quality of course. I belive it does make a difference because it takes 2 people to make a baby. Not just 1. It has to matter in my opinion because each have chromsomes.

Deneice- I was wondering where you got to. Glad to see you had your ER. It shows right there how you and your DH had so many fertlized and the donor did not. Yea they were different eggs but you cant tell me she got the ones that weren't as good. When I had my ER done and they frozen 7 right away and kept the other 7 out. All 14 fertilized. But then they said to me the quality wasn't that good. This is the one Re there that I normally dont see. But my RE says different. Becaue out of gthe 7 only one was 8 cell and a few were 6 cell and the other ones were behind. She told me that I had poor quality eggs and this is probably why IVF is not working for. I was so upset. I said couldn't it be my DH too and she said no it's your eggs. I was thinking how can the embryo quality be only determined by me. Then what about the ones that dont make it for people who carry downsyndrome or something. The father could carry and it then it has chromosome problems. Sorry to go on but I was very upset about this and my RE said they were fine and you know that one turned into a baby and I miscarriaged because of a blood clot. Next time I see her I'll tell her the baby made it to 9 weeks. So dont tell me there was problems and it died from other reasons. Sorry so long but I have a real issue with people throwing out egg quality all the time. Same thing happen to a girl on here as well. They told her that she went to another clinic is now 15 weeks pregnant.
Me (Meredith) 30 DH 31
June 2001- Surprise BFP- Blighted Ovum
TTC since June 2005
DX 2007: Damaged tubes
IUI- April 2007 Tubal Pregnancy
(right tube removed)
IVF #1- September 2007- Chemical Pregnancy
IVF #2- February 2008- OHSS Froze embryos
FET #1- March 2008 - BFN (4 frozen embryos)
IVF #3- May 2008- M/C 10 weeks (10 Frozen embryos)
DX- Blood Clotting disorder
FET#2- February 2009- BFN (2 frozen embryos)
IVF#4- September 2009 BFN ( 2 blasts frozen)
TTC much needed break Sept 09-Sept 11
FET#3- September/October
Transfer October 11
BFP!!! Due June 29

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